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The right trial would be in people w ithout any cognitive impairmen t but at high-risk as defined by family history, high polygenic risk score, APOE4 carrier or homozygotes, high levels of p-Tau217 and other blood biomarkers

Additionally, the metabolic changes associated with significant weight loss and improved glycemic control may temporarily affect energy levels as the body adapts to a new physiological state

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In summary, we provide initial real-world evidence of reduced alcohol consumption in people with obesity taking Semaglutide or Tirzepatide medications, suggesting potential efficacy for treatment in AUD comorbid with obesity